Our Work
Dalton HM, Young NJ, Berman AR, Evans HD, Peterson SJ, Patterson KA, Chow CY. A drug repurposing screen reveals dopamine signaling as a critical pathway underlying potential therapeutics for the rare disease DPAGT1-CDG. PLOS Genetics LINK
Thorpe HJ, Partha R, Little J, Clark NL, Chow CY. Evolutionary rate covariation is pervasive between glycosylation pathways and points to potential disease modifiers. PLOS Genetics 20(9): (2024). LINK
Thorpe HJ*, Owings KG*, Aziz MC*, Haller M, Coelho E, Chow CY. Drosophila models of PIGA-CDG mirror patient phenotypes. G3. 14(3): (2024). LINK *co-first authors Featured article
Owings KG, Chow CY. A Drosophila screen identifies a role for histone methylation in ER stress preconditioning. G3. 14(2): (2024). LINK
Russell ND, Jorde LB, Chow CY. Characterizing genetic variation in the regulation of the ER stress response through computational and cis-eQTL analyses . G3. 13(12): (2023). LINK
Johnstone EB, Gorsi B, Coelho E, Moore B, Farr AM, Cooper AR, Mardis ER, Rajkovic A, Chow CY, Yandell M, Welt CK. DIS3 Variants are Associated with Primary Ovarian Insufficiency: Importance of Transcription/Translation in Oogenesis. J Clin Endocrinol Metab. 108(9): (2023). LINK
Dalton HM*, Viswanatha R*, Brathwaite R Jr, Zuno JS, Berman AR, Rushforth R, Mohr SE, Perrimon N, Chow CY. A genome-wide CRISPR screen identifies DPM1 as a modifier of DPAGT1 deficiency and ER stress. PLOS Genetics 18(9): (2022). LINK *co-first authors
Hope KA, Berman AR, Peterson RT, Chow CY. An in vivo drug repurposing screen and transcriptional analyses reveals the serotonin pathway and GSK3 as major therapeutic targets for NGLY1 deficiency. PLOS Genetics 18(6): (2022). LINK
Russell ND, Chow CY. The dynamic effect of genetic variation on the in vivo ER stress transcriptional response in different tissues. G3. 12(6): (2022). LINK
Gorsi B, Hernandez E, Moore MB, Moriwaki M, Chow CY, Coelho E, Taylor E, Lu C, Walker A, Touraine P, Nelson LM, Cooper AR, Mardis ER, Rajkovic A, Yandell M, Welt CK. Causal and candidate gene variants in a large cohort of women with primary ovarian insufficiency. JCEM. 107(3): (2022). LINK
Talsness DM*, Owings KG*, Coelho E, Mercenne G, Pleinis JM, Zuberi AR, Partha R, Hope KA, Clark NL, Lutz CM, Rodan AR, Chow CY. A Drosophila screen identifies NKCC1 as a modifier of NGLY1 deficiency. eLife. 9: e57831: (2020). LINK PDF *co-first authors
Palu RAS, Dalton HM, Chow CY. Decoupling of Apoptosis from Activation of the ER Stress Response by the Drosophila Metallopeptidase superdeath. Genetics. 214(4): (2020). LINK PDF
Ahlers RHL, Trammell CE, Carrell GF, Mackinnon S, Torrevillas BK, Chow CY, Luckhart S, Goodman AG. Insulin potentiates JAK/STAT signaling to broadly inhibit flavivirus replication in insect vectors. Cell Reports. 29(7): (2019). LINK PDF *read Crosscut and WSU coverage of this work
Palu RAS, Ong E, Stevens K, Chung S, Owings KG, Goodman AG, Chow CY. Natural genetic variation screen in Drosophila identifies Wnt signaling, mitochondrial metabolism, and redox homeostasis genes as modifiers of apoptosis. G3. 9(12): (2019). LINK PDF
Palu RAS, Chow CY. Baldspot/ELOVL6 is a conserved modifier of disease and the ER stress response. PLOS Genet. 14(8): (2018). LINK PDF *Listen to postdoc Rebecca Palu discuss her results on Utah Public Radio
Lavoy S, Chittoor-Vinod VG, Chow CY, Martin I. Genetic Modifiers of Neurodegeneration in a Drosophila Model of Parkinson's Disease. Genetics. 209(4): (2018). LINK PDF
Owings KG, Lowry JB, Bi Y, Might M, Chow CY. Transcriptome and functional analysis in a Drosophila model of NGLY1 deficiency provides insight into therapeutic approaches. Hum. Mol. Gen. 27(6): (2018). LINK PDF
Chow CY, Reiter LT. Etiology of Human Genetic Disease on the Fly. Trends Genet. 17: (2017). LINK PDF
Chow CY. Bringing genetic background into focus. Nature Reviews Genetics. 17(2): (2016). LINK PDF
Chow CY, Kelsey K, Wolfner MF, Clark AG. Candidate genetic modifiers of retinitis pigmentosa identified by exploiting natural variation in Drosophila. Hum. Mol. Gen. 25(4): (2016). LINK PDF *Listen to Clement discuss implications of study
Chow CY, Avila F, Wolfner MF, Clark AG. Induction of excessive endoplasmic reticulum stress in the Drosophila male accessory gland results in infertility. PLOS ONE. 10(3): (2015). LINK PDF
Chow CY, Wang X, Riccardi D, Wolfner MF, Clark AG. The genetic architecture of the genome-wide transcriptional response to ER stress in the mouse. PLOS Genet. 11(2): (2015). LINK PDF see Cornell Chronicle coverage
Chow CY, Wolfner MF, Clark AG. Using natural variation in Drosophila to discover previously unknown endoplasmic reticulum stress genes. PNAS. 110(22): 9013-9018 (2013). LINK PDF
Chow CY, Wolfner MF, Clark AG. A large neurological component to genetic differences underlying biased sperm use in Drosophila. Genetics. 193(1):177-8 (2013). LINK PDF
Lenk GM, Ferguson CJ, Chow CY, Jin N, Jones JM, Grant AE, Zolov SN, Winters JJ, Giger RJ, Dowling JJ, Weisman LS, Meisler MH. Pathogenic mechanism of the FIG4 mutation responsible for Charcot-Marie-Tooth disease CMT4J. PLOS Genet. Jun 7(6) (2011). LINK PDF
Im KM, Kirchhoff T, Wang X, Green T, Chow CY, et al. Haplotype Structure in Ashkenazi Jewish BRCA1 and BRCA2 Mutation Carriers. Hum Genet. 130(5):685-99 (2011). LINK PDF
Chow CY, Wolfner MF, Clark AG. The Genetic Basis for Male x Female Interactions Underlying Variation in Reproductive Phenotypes of Drosophila. Genetics. 186(4):1355-65 (2010). LINK PDF
Sirot LK, LaFlamme BA, Stitnik JL, Rubinstein CD, Avila FW, Chow CY, Wolfner, MF. Molecular social interactions: Drosophila melanogaster seminal fluid proteins as a case study. Adv. Genet. 68: 23-56 (2009). LINK PDF
Chow CY, Landers JE, Bergren SK, Sapp PC, Grant AE, Jones JM, Everett L, Lenk GM, McKenna-Yasek DM, Weisman LS, Figlewicz D, Brown RH, Meisler MH. Deleterious Variants of FIG4, a Phosphoinositide Phosphatase, in Patients with ALS. Am J Hum Genet. 84(1):85-8 (2009). LINK PDF
Jin N*, Chow CY*, Liu L, Zolov SN, Bronson R, Davisson M, Petersen JL, Zhang Y, Park S, Duex JE, Goldowitz D, Meisler MH and Weisman LS. VAC14 nucleates a protein complex that is essential for the regulation of PI(3,5)P2 levels in yeast and mouse. EMBO J. (27), 3221-34 (2008). LINK PDF
*co-first authors
Zhang X, Chow CY, Sahenk Z, Shy M, Meisler M, Li J. Mutation of FIG4 causes a rapidly progressive, asymmetric neuronal degeneration. Brain 131, 1990-2001 (2008). LINK PDF
McKinney B, Chow CY, Meisler M, Murphy G. Exaggerated emotional behavior in mice heterozygous null for the sodium channel Scn8a (Nav1.6). Genes, brain, and behavior 7 (6), 629-38 (2008). LINK PDF
Zhang Y, Zolov S, Chow CY, Slutsky S, Richardson S, Piper R, Yang B, Nau J, Westrick R, Morrison S, Meisler M, Weisman L. Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice. PNAS 104 (44), 17518-23 (2007). LINK PDF see press release
Chow CY, Zhang Y, Dowling J, Jin N, Adamska M, Shiga K, Szigeti K, Shy M, Li J, Zhang X, Lupski J, Weisman L, Meisler M. Mutation of FIG4 causes neurodegeneration in the pale tremor mouse and patients with CMT4J. Nature 448 (7149), 68-72 (2007). LINK PDF see press release